Shortly before noon Wednesday, firefighters battled a blaze at a home located at 5856 Fisherville Road.
Simpsonville Fire Chief Walter Jones said the call came in at about 11:19 a.m. that a structure fire was in progress.
Firefighters arrived to find flames shooting from the upper floor of the two-story home.
The home is owned by Kurt Swigert, Jones said.
Swigert was not living in the home at the time of the blaze but Jones said several Hispanic residents who do work for him had been staying in the house. They were not injured.